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KMID : 0880220210590110988
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Journal of Microbiology
2021 Volume.59 No. 11 p.988 ~ p.1001
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The comparison of microbial communities in thyroid tissues from thyroid carcinoma patients
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Liu Chen-Jian
Chen Si-Qian
Zhang Si-Yao
Wang Jia-Lun
Tang Xiao-Dan
Yang Kun-Xian
Li Xiao-Ran
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Abstract
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Thyroid carcinoma is a common endocrine organ cancer associated with abnormal hormone secretion, leading to the disorder of metabolism. The intestinal microbiota is vital to maintain digestive and immunologic homeostasis. The relevant information of the microbial community in the gut and thyroid, including composition, structure, and relationship, is unclear in thyroid carcinoma patients. A total of 93 samples from 25 patients were included in this study. The results showed that microbial communities existed in thyroid tissue; gut and thyroid had high abundance of facultative anaerobes from the Proteobacteria phyla. The microbial metabolism from the thyroid and gut may be affected by the thyroid carcinoma cells. The cooccurrence network showed that the margins of different thyroid tissues were unique areas with more competition; the stabilization of microcommunities from tissue and stool may be maintained by several clusters of species that may execute different vital metabolism processes dominantly that are attributed to the microenvironment of cancer.
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KEYWORD
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thyroid carcinoma, thyroid microbiota, cooccurrence network, Tax4Fun2, gut microbiota
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